IL-10, IL-13, Eotaxin and IL-10/IL-6 ratio distinguish breast implant-associated anaplastic large-cell lymphoma from all types of benign late seromas

Breast implant-associated anaplastic large-cell lymphoma (BI-ALCL) is an uncommon peripheral T cell lymphoma usually presenting as a delayed peri-implant effusion. Chronic inflammation elicited by the implant has been implicated in its pathogenesis. Infection or implant rupture may also be responsible for late seromas. Cytomorphological examination coupled with CD30 immunostaining and eventual T-cell clonality assessment are essential for BI-ALCL diagnosis. However, some benign effusions may also contain an oligo/monoclonal expansion of CD30 + cells that can make the diagnosis challenging. Since cytokines are key mediators of inflammation, we applied a multiplexed immuno-based assay to BI-ALCL seromas and to different types of reactive seromas to look for a potential diagnostic BI-ALCL-associated cytokine profile. We found that BI-ALCL is characterized by a Th2-type cytokine milieu associated with significant high levels of IL-10, IL-13 and Eotaxin which discriminate BI-ALCL from all types of reactive seroma. Moreover, we found a cutoff of IL10/IL-6 ratio of 0.104 is associated with specificity of 100% and sensitivity of 83% in recognizing BI-ALCL effusions. This study identifies promising biomarkers for initial screening of late seromas that can facilitate early diagnosis of BI-ALCL

Tra parole e immagini: come leggere la lettura

Il progetto trae origine da una ricerca condotta sulla promozione della lettura a Torino i cui primi risultati sono confluiti in una tesi di laurea discussa nel novembre 2010 da Sara Marchisio. I risultati dello studio, che prende le mosse dall’analisi del concetto della lettura e delle molteplici prospettive da cui può essere analizzata, sono stati illustrati in Leggere a Torino. Modelli ed esperienze di promozione della lettura, «Libri e riviste d’Italia», 7, 2011, 1-2, pp. 43-56. Per promu..

Dalla "Biblioteca Pia" alla "Biblioteca Generale della Pontificia Universit\ue0 Lateranense": un percorso storico-bibliografico

Il lavoro di ricerca \ue8 stato dedicato alla ricostruzione della "Privata biblioteca di Papa Pio IX", attualmente conservata presso la Biblioteca della Pontificia Universit\ue0 Lateranense, attraverso la trascrizione di tutti i lemmi registrati nell'"Indice componente la privata Biblioteca di Papa pio 9. felicemente regnante" e attraverso un loro riscontro collazionale con differenti cataloghi autorevol

B4GALT1 as a New Biomarker of Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a disease characterized by progressive scarring of the lung that involves the pulmonary interstitium. The disease may rapidly progress, leading to respiratory failure, and the long-term survival is poor. There are no accurate biomarkers available so far. Our aim was to evaluate the expression of the B4GALT1 in patients with IPF. Analysis of B4GALT1 gene expression was performed in silico on two gene sets, retrieved from the Gene Expression Omnibus database. Expression of B4GALT1 was then evaluated, both at the mRNA and protein levels, on lung specimens obtained from lung biopsies of 4 IPF patients, on one IPF-derived human primary cell and on 11 cases of IPF associated with cancer. In silico re-analysis demonstrated that the B4GALT1 gene was overexpressed in patients and human cell cultures with IPF (p = 0.03). Network analysis demonstrated that B4GALT1 upregulation was correlated with genes belonging to the EMT pathway (p = 0.01). The overexpression of B4GALT1 was observed, both at mRNA and protein levels, in lung biopsies of our four IPF patients and in the IPF-derived human primary cell, in other fibrotic non-lung tissues, and in IPF associated with cancer. In conclusion, our results indicate that B4GALT1 is overexpressed in IPF and could represent a novel marker of this disease

1. Seminario Nazionale di Biblioteconomia

DIDATTICA E RICERCA NELL’UNIVERSITA ITALIANA E CONFRONTI INTERNAZIONALI Il volume raccoglie la maggior parte dei contributi che sono stati presentati e discussi il 30 e 31 maggio 2013, nel corso del primo “Seminario nazionale di biblioteconomia” organizzato, nell’ambito delle attività scientifiche del Dipartimento di Scienze documentarie, linguistico-filologiche e geografiche dell’Università di Roma La Sapienza, da Alberto Petrucciani e Giovanni Solimine, con il patrocinio della Facoltà di Lettere, dell’Associazione italiana biblioteche (AIB) e della Società italiana di scienze bibliografiche e biblioteconomiche (SISBB)